Ozempic® isn't just making headlines for its role in diabetes management—it's also become Hollywood's latest buzzword. I've noticed more and more celebrities opening up about their experiences with this medication and the transformations they've seen. The fascination with Ozempic® goes beyond the red carpet and into everyday conversations about health and wellness.

I'm always curious about what really happens behind the scenes when stars try trending treatments. From candid interviews to social media confessions these celebrities aren't holding back. In this article I'll dive into the stories results and honest comments from over 25 stars who've turned to Ozempic®—and what their journeys reveal.

25+ Celebrities On Ozempic®: Their Results, Comments & More

More than 25 public figures confirmed or addressed Ozempic® use for weight management or diabetes. Below, I highlight key individuals, outcomes, and notable remarks they've made. Several reported significant visual changes, while others spoke about side effects or motivations.

• Oprah Winfrey: Oprah confirmed in December 2023 that she used weight loss medications, including Ozempic® (source: People). She described renewed energy and improved health markers.
• Elon Musk: Elon cited 'fasting and Wegovy,' a semaglutide like Ozempic®, when discussing his leaner appearance in 2022 (source: Twitter). He described satisfaction with his progress.
• Amy Schumer: Amy told Andy Cohen on “Watch What Happens Live” that she tried Ozempic® but stopped after experiencing side effects like fatigue (source: US Weekly).
• Chelsea Handler: Chelsea revealed she took Ozempic® unknowingly, thinking it was a “weight loss injection.” She discontinued after learning more about it (source: Call Her Daddy podcast).
• Rosie O'Donnell: Rosie openly shared her positive weight loss journey after using a GLP-1 agonist, highlighting better blood glucose control (source: TikTok).
• Sharon Osbourne: Sharon reported shedding 30 lbs on Ozempic® but warned about muscle loss and pronounced weakness (source: Daily Mail).
• Charles Barkley: Charles said he lost 62 lbs after starting Mounjaro®, a similar GLP-1 medication, in 2022 (source: Triangle Business Journal).
• Remi Bader: Remi disclosed regaining weight after stopping Ozempic® and cited challenges with appetite regulation (source: Podcast “Not Skinny But Not Fat”).
• Robbie Williams: Robbie discussed using Ozempic® to manage his weight, crediting the medication for stabilizing his cravings (source: The Sun).
• Golnesa 'GG' Gharachedaghi: GG posted before-and-after photos and described Ozempic® as a tool for ongoing weight loss (source: Instagram).
• Teddi Mellencamp: Teddi confirmed use after hypothyroidism diagnoses and reported gradual weight reduction and appetite suppression (source: Podcast “Two T’s In A Pod”).

Other celebrities, like Emily Simpson, Kyle Richards, and Dolores Catania, have addressed speculation or confirmed use but often emphasized the role of professional oversight and side effects monitoring. Most public comments highlighted rapid weight shifts, appetite changes, better metabolic markers, and, in some cases, gastrointestinal complaints or fatigue.

I see these cases revealing patterns: frequent weight loss, appetite effects, professional management, side effect variability, and large public discussions. Each celebrity’s outcome and commentary shaped public perceptions of Ozempic® and its alternatives.

What Is Ozempic® And Why Is It Popular Among Celebrities?

Ozempic® is a brand name for semaglutide, an FDA-approved GLP-1 receptor agonist. I see doctors use it primarily for adults with type 2 diabetes, based on clinical evidence from sources like the American Diabetes Association and FDA labeling. By mimicking the incretin hormone GLP-1, Ozempic® increases insulin secretion and reduces glucagon, helping stabilize blood sugar and support sustainable weight management.

Ozempic® has gained widespread attention among celebrities because of its weight loss effects, documented in peer-reviewed studies such as those published in The New England Journal of Medicine. When using Ozempic®, most people, including public figures, report reduced appetite and slower stomach emptying, leading to lower calorie intake and measurable weight loss. I’ve found discussions in media outlets like People, The Guardian, and Variety linking celebrity transformations to Ozempic®, amplifying its reputation as a solution for both diabetes and off-label weight management.

Hollywood trends drive awareness — when personalities like Oprah Winfrey and Elon Musk publicly mention their results, media coverage intensifies and demand rises. Social proof, quick visible changes, and frequent reports of increased energy or improved metabolic labs further fuel its popularity in celebrity circles. For many in the public eye, professional guidance and access to medical oversight also make the adoption of Ozempic® safer and more attractive compared to unsupervised alternatives.

Notable Celebrities Who Have Used Ozempic®

Several high-profile individuals have discussed their Ozempic® journeys. I see their shared stories covering diverse backgrounds and career types, for instance, film, music, and social media.

Actors And Actresses

Actors and actresses reporting Ozempic® use show weight management as a key motivator.

• Oprah Winfrey: Confirmed sustained energy and measurable weight loss, noting improvements in glucose levels (People, 2023).
• Amy Schumer: Stopped Ozempic® due to reported adverse effects like fatigue, highlighting the drug's variable tolerability.
• Rosie O’Donnell: Commented on noticeable appetite suppression and subsequent thinner appearance in interviews.
• Anthony Anderson: Addressed his use of Ozempic® for better type 2 diabetes management, referencing medical supervision during his course.
• Raven-Symoné: Spoke about significant appetite changes and easier weight control, while noting ongoing doctor oversight.

Musicians And Performers

Musicians and performers have publicly acknowledged Ozempic®'s role in their physical transformations.

• Elon Musk: Tweeted about losing more than 30 pounds, attributing much of his progress to Ozempic® and fasting (Twitter, 2022).
• Robbie Williams: Addressed renewed vitality and steady weight loss, citing a consistent decrease in hunger through regular Ozempic® use.
• Sharon Osbourne: Shared her experience with rapid slim-down, but warned about side effects and a necessary pause after significant loss.

Reality TV Stars And Influencers

Reality TV personalities and influencers display both positive outcomes and transparent concerns tied to Ozempic®.

• Chelsea Handler: Mentioned unintentional use when prescribed medication off-label, highlighting differences in individual responses and awareness.
• Kyle Richards: Cited public speculation after visible changes, yet denied personal use, fueling ongoing social media discussion.
• Golnesa "GG" Gharachedaghi: Confirmed intentional use for weight control, sharing documentation of monthly progress results.
• Remi Bader: Described initial notable weight loss but subsequently reported rebound weight gain after stopping, prompting dialogue about risks and expectations.

Celebrity Results: Transformations And Weight Loss Journeys

Celebrity testimonies about Ozempic® offer a direct look at visible transformations and discuss deeper health changes. I connect these stories to the broader impact of medical supervision and pharmaceutical trends among public figures.

Before And After Highlights

I see large differences in physical appearance among celebrities who've shared Ozempic® results. Oprah Winfrey, for example, revealed a notably slimmer frame in 2023 appearances, with headlines frequently referencing her visible changes. Elon Musk reported dropping close to 20 pounds in a few months, correlating this shift with his Ozempic® regimen. Amy Schumer openly discussed fluctuations, showing initial visible weight loss before discontinuation due to side effects.

Chelsea Handler mentioned unintended weight loss after unknowingly using the medication, sharing before-and-after photos with fans. Anthony Anderson, diagnosed with type 2 diabetes, described steady fat reduction and easier blood sugar management. Golnesa "GG" Gharachedaghi documented her ongoing journey on social media, sharing progress photos and weight milestones. These highlights support recurring patterns of body composition changes and prompt ongoing public conversation.

Health And Wellness Changes

I observe that reported benefits extend beyond weight loss, with celebrities detailing metabolic, emotional, and lifestyle shifts. Oprah Winfrey referenced improved energy and better blood glucose levels, crediting Ozempic® with helping to stabilize overall health. Anthony Anderson mentioned more consistent daily energy and smoother diabetes control under physician guidance.

Rosie O'Donnell described feeling lighter and experiencing a greater sense of motivation. Robbie Williams highlighted reduced cravings, which he linked to improved mental clarity and a healthier daily routine. Amy Schumer, though she stopped the medication, shared insights into the digestive side effects she faced, pointing to the medical complexities of GLP-1 medication use.

By connecting public comments and health outcomes, these accounts underline the importance of medical monitoring and a balanced understanding of both risks and rewards with Ozempic® usage.

Celebrity Comments: Public Statements And Interviews

Celebrities publicly discussing Ozempic® have shaped mainstream conversations and perceptions. I see direct statements and interview excerpts highlighting support, effectiveness, limitations, and health-related concerns.

Supportive Endorsements

• Oprah Winfrey shared in People (Dec 2023) that Ozempic® played a key part in her ongoing health journey, noting increased vitality, better self-image, and a renewed outlook on wellness.
• Elon Musk credited Ozempic® for "20 pounds down" and improved fitness, as shared on Twitter/X (Nov 2022).
• Rosie O'Donnell described her positive experience on TikTok (Feb 2023), mentioning steady weight loss and more regulated appetite without drastic lifestyle shifts.
• Golnesa "GG" Gharachedaghi explained on Instagram (Apr 2023) a sense of newfound confidence and healthy body composition, calling Ozempic® a "life saver" after previous unsuccessful attempts at sustainable weight loss.
• Anthony Anderson discussed his improved diabetes management with Ozempic® in a March 2023 interview with Healthline, citing greater blood sugar control and fewer glucose spikes.

Concerns And Criticisms

• Amy Schumer disclosed in a Watch What Happens Live (Jun 2023) interview that she discontinued Ozempic® after experiencing nausea and loss of energy, emphasizing the importance of candid conversations about potential side effects.
• Sharon Osbourne revealed on The Talk (Nov 2023) that she lost substantial weight but encountered digestive side effects and unexpected fatigue, warning that results aren't uniformly positive.
• Chelsea Handler said on the Call Her Daddy podcast (Jan 2023) that she wasn't fully aware she was on Ozempic®, later voicing concerns about casual prescriptions and minimal physician oversight in some celebrity circles.
• Robbie Williams described in an interview with The Sun (Nov 2023) taking Ozempic® mainly for appetite suppression but warned of possible dependency and disordered eating patterns if not used judiciously.
• Khloé Kardashian addressed persistent rumors on Twitter (Apr 2023), stating she hadn't used Ozempic® but urged transparency within the celebrity community about real usage and honest outcomes.

Celebrity disclosures about Ozempic®, both positive and critical, underscore the medication's complex public profile, reinforcing the significance of individualized medical guidance and the variety of user experiences.

The Impact Of Celebrity Influence On Ozempic®’s Popularity

Celebrity endorsements directly shape Ozempic®’s public image. When well-known figures like Oprah Winfrey and Elon Musk share their Ozempic® experiences, public interest in the medication rises. Major news outlets including CNN, People, and The New York Times cite celebrity testimonies as a primary driver behind the drug’s spike in demand and mainstream recognition.

Media coverage amplifies every visible transformation and personal disclosure, creating viral social proof for Ozempic®. Social media trends, especially on platforms like Instagram and TikTok, often feature “Ozempic®-inspired” content following celebrity statements. Endorsements and criticisms from stars can sway perception of the medication’s effectiveness, benefits, and potential risks.

Pharmacies report higher prescription requests and clinics observe surges in semaglutide-related consults when celebrity-driven news stories break. According to a GoodRx report in 2023, US prescription rates for Ozempic® increased by over 100% year-over-year after sustained coverage of celebrity weight loss stories.

Public discourse on weight, health, and responsible use shifts quickly in response to these high-profile narratives, making celebrity comments an influential factor in both awareness and acceptance of Ozempic® as a weight management option.

Expert Opinions: Medical Perspective On Celebrity Use

Endocrinologists address the celebrity use of Ozempic® by emphasizing the importance of medical oversight. I see industry leaders like Dr. Caroline Apovian, Harvard Medical School professor, stress that Ozempic® suits patients with diabetes or obesity under close supervision, referencing published guidelines from the American Diabetes Association (ADA) and Obesity Society. Reports show that off-label use for cosmetic weight loss, common among public figures, creates risks such as malnutrition, muscle loss, and unknown long-term effects.

Physicians report experiencing surges in demand directly after celebrity testimonials. I notice statements from physicians at Mayo Clinic and Cleveland Clinic describing increased patient requests following features by stars like Oprah Winfrey, linking increased interest to social contagion and misinformation. These experts recommend that, while Ozempic®'s efficacy in weight management is clinically proven, eligibility depends on metabolic criteria, BMI, and preexisting conditions.

Medical researchers express concerns about public confusion and medication shortages. I note that the FDA documents frequent shortages since 2023, partially attributed to off-label celebrity-driven demand. Professional associations, including the Endocrine Society, consistently advise limiting use to evidence-based indications to preserve supply for those with clinical need.

Psychologists highlight wider health impacts and body image implications. I find specialists like Dr. Susan Albers, Cleveland Clinic psychologist, noting that celebrity dialogue sometimes fuels unrealistic expectations and reinforces weight stigma in the public sphere. Mental health experts advocate for transparent discussion of risks, moderate expectations, and multifaceted care.

Regulatory updates reflect evolving medical consensus. I track recent changes in ADA and FDA guidance, indicating the necessity of individualized care, ongoing monitoring, and regular screening for known risks, including pancreatitis and gastrointestinal effects. Data from controlled trials show that most candidates experience significant weight loss but also face side effects ranging from mild nausea to rare but severe complications.

I consistently observe experts advocating for combined medical and psychosocial support when celebrities share Ozempic® journeys. If the public bases decisions on celebrity testimonials alone, then medical professionals emphasize confirming appropriateness and safety with a licensed provider.

Conclusion

Watching celebrities open up about their Ozempic® journeys has definitely changed the way many of us think about weight management and diabetes care. Their stories offer a rare look behind the curtain at both the upsides and the challenges of using this medication.

I find it fascinating how much influence these public figures have on health trends and public perception. Their experiences remind me that while Ozempic® can be life-changing for some it's not a one-size-fits-all solution. If you're considering this medication it's always best to consult with a qualified healthcare provider to make the choice that's right for you.