FODMAP Digestive Enzymes | Low FODMAP Gut Friendly Support for Heavy Meals & Bloating

FODMAP Friendly certified · Formulated by Onikepe Adegbola, MD PhD · Third-party tested

Break Down Heavy Meals and Prevent Digestive Discomfort

These MD PhD-formulated FODMAP Digestive Enzymes take the heavy lifting out of digestion. Whether you're navigating complex IBS trigger foods or managing the delayed gastric emptying of GLP-1 therapy, our physician-formulated multi-enzyme blend helps your body break down fats, carbs, and proteins for a lighter, more comfortable post-meal experience.

Why Both Low FODMAP & GLP-1 Users Love It

For GLP-1 Therapy: Because GLP-1 medications slow down how quickly food leaves your stomach, even normal meals can sit heavily and cause nausea, reflux, or extreme fullness. These enzymes accelerate food breakdown, drastically reducing that heavy "food coma" feeling.

For IBS & Food Intolerances: Features an 18-enzyme blend meticulously designed to target difficult-to-digest fermentable carbs (FODMAPs), helping to proactively prevent the gas, bloating, and pain associated with eating trigger foods.

How to Use: Take 1–2 capsules at the very first bite of any meal that typically causes fullness or discomfort.

Learn more: Casa de Sante vs FODZYME: Low FODMAP Digestive Enzymes

Evidence and quality

• FODMAP Friendly certified - the finished product is certified, not just "low FODMAP by ingredient".
• Third-party tested, cGMP facility - independent lab verified.
• Formulated by Onikepe Adegbola, MD, PhD, physician and gut-health researcher.
• What enzymes cannot do: they do not cure IBS, SIBO, or food allergy, and they do not remove fructans from wheat, garlic, or onion. They reduce the digestive load of a meal.

Product facts last verified September 16, 2026 by the Casa de Sante team.

Frequently asked questions

Do digestive enzymes help with FODMAP intolerance?

Enzymes can only help with the FODMAPs their enzymes actually target. Our 18-enzyme blend includes alpha-galactosidase (GOS in beans and legumes), lactase (lactose), and carbohydrase activity for starches, plus proteases and lipases for protein and fat in heavy meals. Enzymes do not remove fructans from wheat, garlic, or onion, and they do not treat IBS. Use them alongside a low FODMAP plan, not instead of one.

When should I take FODMAP Digestive Enzymes?

Take 1-2 capsules with the first bite of the meal. Enzymes work while food is in the stomach and upper small intestine, so taking them after you finish eating gives them less to act on.

Are Casa de Sante FODMAP Digestive Enzymes third-party tested?

Yes. The product is FODMAP Friendly certified, third-party tested, and made in a cGMP facility. It was formulated by Onikepe Adegbola, MD, PhD.

Can I take these while on a GLP-1 medication (semaglutide or tirzepatide)?

Many people on GLP-1 therapy use enzymes to make large or fatty meals feel lighter, because GLP-1 medicines slow gastric emptying. Enzymes do not change how the medication works, do not treat nausea or gastroparesis, and are not a substitute for the dose and diet guidance from your prescriber. Ask your clinician first if you have persistent vomiting, severe reflux, or unexplained weight loss.

Who should not use these enzymes?

Do not use if you are allergic to any listed ingredient, and check with a clinician first if you are pregnant or breastfeeding, under 18, taking blood thinners or diabetes medication, or have pancreatitis, active pancreatic disease, or a history of gastrointestinal surgery. Stop use and speak to a clinician if you develop new abdominal pain.

How is this different from a single-enzyme FODMAP powder?

Single-enzyme products target one FODMAP group, most often GOS and lactose, and are dosed onto the food. This is a capsule with an 18-enzyme blend covering fats, starches, proteins, and several FODMAP groups in one dose, which is why people use it for whole meals out rather than one known trigger ingredient.