Is Mastic Gum High In Histamine

Mastic gum has been gaining popularity in recent years for its potential health benefits. Among its many uses, it has been suggested that mastic gum may help regulate histamine levels in the body. But is mastic gum actually high in histamine? In this article, we will explore the relationship between mastic gum and histamine, as well as its potential health implications.

Understanding Mastic Gum

Mastic gum, also known as Chios gum, is a resinous substance derived from the mastic tree, scientifically known as Pistacia lentiscus. This tree is primarily found in the Mediterranean region, particularly on the Greek island of Chios. For centuries, mastic gum has been used both as a natural remedy and as a culinary ingredient.

In traditional medicine, mastic gum has been used to promote digestive health and to alleviate symptoms of indigestion. It has also been used for its antimicrobial properties, as it was believed to help fight bacteria and other pathogens in the body.

But what makes mastic gum so special? Let's delve deeper into its origin and uses to uncover its fascinating properties.

Origin of Mastic Gum

The mastic tree, Pistacia lentiscus, is an evergreen shrub that belongs to the cashew family. It thrives in the Mediterranean climate, with its natural habitat extending from Greece to Turkey and other parts of the region. However, it is on the Greek island of Chios where the mastic tree truly flourishes.

Chios has a unique microclimate that provides the perfect conditions for the mastic tree to grow. The island's soil composition, coupled with the warm summers and mild winters, creates an ideal environment for the tree's resin to develop and mature.

Harvesting mastic gum is a labor-intensive process that has been passed down through generations on Chios. The resin is extracted by making small incisions in the bark of the tree, allowing the sap to ooze out. This sap is then left to dry and harden, forming the precious mastic gum.

Uses of Mastic Gum

Mastic gum has a long history of use in various cultures, and its versatility is truly remarkable. Not only is it valued for its potential health benefits, but it is also highly regarded in the culinary world.

In traditional Greek cuisine, mastic gum is a cherished ingredient, adding a unique flavor and aroma to dishes. It is commonly used in desserts, such as ice cream, pastries, and puddings, where it imparts a subtle pine-like taste and a refreshing scent.

Aside from its culinary applications, mastic gum has been used for its medicinal properties for centuries. In addition to aiding digestion and combating bacteria, it has been associated with other potential health benefits.

Research suggests that mastic gum may have anti-inflammatory effects, making it a potential natural remedy for conditions such as inflammatory bowel disease. It has also been studied for its potential to support oral health, with some evidence suggesting that it may help combat gum disease and reduce bad breath.

Furthermore, mastic gum has been explored for its potential to support skin health. It is believed to possess antioxidant properties, which may help protect the skin from oxidative damage caused by free radicals.

Active Components of Mastic Gum

One of the main active components found in mastic gum is mastiha, a resin that is responsible for many of its potential health benefits. Mastiha contains a number of bioactive compounds, including triterpenic acids, volatile oils, and antioxidants.

Triterpenic acids are known for their anti-inflammatory properties, which may contribute to the potential therapeutic effects of mastic gum. These compounds have been studied for their ability to reduce inflammation in the body and alleviate symptoms associated with various inflammatory conditions.

The volatile oils found in mastic gum are responsible for its distinct aroma and flavor. These oils contain compounds that may have antimicrobial properties, potentially helping to combat harmful bacteria and other pathogens.

Antioxidants, another group of bioactive compounds present in mastic gum, play a crucial role in protecting the body against oxidative stress. They help neutralize harmful free radicals, which can cause cellular damage and contribute to various diseases.

These compounds are thought to contribute to the various properties attributed to mastic gum, including its potential to regulate histamine levels in the body. Histamine is a compound involved in allergic reactions and inflammatory responses, and maintaining its balance is important for overall health and well-being.

As you can see, mastic gum is not just a simple resinous substance. Its rich history, diverse uses, and active components make it a fascinating natural product with potential health benefits. Whether enjoyed in a delicious dessert or used as a natural remedy, mastic gum continues to captivate and intrigue those who discover its unique properties.

Histamine: A Comprehensive Exploration

What is Histamine?

Histamine, a fascinating compound, is naturally produced by the body and plays a pivotal role in several key physiological processes. It functions as a chemical messenger, mediating the body's immune response, regulating gastric acid secretion, and even playing a role in neurotransmission.

While histamine is essential for normal bodily functions, it is crucial to maintain a delicate balance. Excessively high levels of histamine can lead to allergic reactions and other health issues.

Role of Histamine in the Body

One of histamine's primary functions is its involvement in the inflammatory response. When the body detects a threat, such as an allergen or pathogen, histamine is released from specialized cells called mast cells. This release triggers a cascade of immune responses, orchestrating a defense mechanism that is both intricate and awe-inspiring.

Upon histamine release, vasodilation occurs, leading to the widening of blood vessels. This phenomenon allows for increased blood flow to the affected area, facilitating the delivery of immune cells and necessary nutrients. Moreover, histamine increases vascular permeability, enabling immune cells to move more freely from the bloodstream into the surrounding tissues.

Furthermore, histamine acts as a powerful recruiter, summoning immune cells to the site of infection or injury. These immune cells, such as neutrophils and macrophages, swiftly arrive to eliminate the threat and initiate the healing process. The orchestration of these immune responses highlights the intricate dance between histamine and the body's immune system.

Aside from its role in the immune response, histamine also plays a crucial role in gastrointestinal health. It aids in the regulation of gastric acid secretion, which is vital for the digestion of food. By stimulating the release of gastric acid, histamine ensures that the stomach has the necessary acidity to break down complex food molecules into simpler forms that can be absorbed and utilized by the body.

Moreover, histamine is not limited to the immune system and the digestive system. It also acts as a neurotransmitter in the central nervous system, participating in the complex communication network between nerve cells. This involvement in neurotransmission highlights the multifaceted nature of histamine and its impact on various physiological processes.

In conclusion, histamine is a remarkable compound that serves as a chemical messenger, regulating immune responses, aiding in digestion, and participating in neurotransmission. Its intricate involvement in these physiological processes showcases the complexity of the human body and the marvels of nature's design.

Mastic Gum and Histamine Levels

Mastic Gum's Effect on Histamine

While mastic gum has been traditionally used for its numerous health benefits, including its potential role in histamine regulation, scientific research on this specific aspect is still limited.

However, some studies suggest that mastic gum may help lower histamine levels in the body. This could potentially be attributed to its antioxidant and anti-inflammatory properties.

By reducing inflammation and oxidative stress, mastic gum may help modulate histamine release and prevent excessive histamine accumulation in the body.

Furthermore, mastic gum has been found to have other potential health benefits. For example, it has been shown to have antibacterial properties, which may help in maintaining a healthy gut microbiota. A study published in the Journal of Medicinal Food found that mastic gum extract exhibited significant antibacterial activity against various strains of bacteria, including Helicobacter pylori, a bacterium known to cause stomach ulcers.

In addition, mastic gum has been studied for its potential anticancer properties. Research published in the journal PLOS ONE demonstrated that mastic gum extract inhibited the growth of human colorectal cancer cells in laboratory experiments. This suggests that mastic gum may have a role in cancer prevention and treatment, although further research is needed to fully understand its mechanisms of action.

Scientific Research on Mastic Gum and Histamine

Although more studies are needed to fully understand the relationship between mastic gum and histamine levels, preliminary research has shown promising results.

One study published in the Journal of Agricultural and Food Chemistry found that mastic gum extract exhibited potent anti-inflammatory effects and significantly inhibited the release of histamine from mast cells in laboratory experiments. These findings suggest a potential inhibitory effect of mastic gum on histamine release.

Another study published in the Journal of Nutrition revealed that mastic gum extract had antioxidant properties and exhibited protective effects against oxidative stress-induced damage, which is known to contribute to histamine release.

Moreover, mastic gum has been investigated for its potential use in managing gastrointestinal disorders. A study published in the World Journal of Gastroenterology reported that mastic gum supplementation improved symptoms and quality of life in patients with functional dyspepsia, a common digestive disorder characterized by recurring pain or discomfort in the upper abdomen.

Furthermore, mastic gum has been found to have antimicrobial effects against various bacteria and fungi. Research published in the Journal of Ethnopharmacology demonstrated that mastic gum extract inhibited the growth of several strains of bacteria, including Staphylococcus aureus and Escherichia coli, as well as the fungus Candida albicans.

Overall, while the current scientific research on mastic gum and histamine levels is still limited, preliminary studies suggest that mastic gum may have potential benefits in modulating histamine release and reducing inflammation. Additionally, mastic gum has shown promise in other areas, such as its antibacterial, anticancer, and gastrointestinal health properties. Further research is needed to fully understand the mechanisms of action and therapeutic potential of mastic gum.

Potential Health Implications

Risks of High Histamine Levels

Excessively high histamine levels in the body can lead to various health issues, such as allergic reactions, asthma, digestive disorders, and skin problems. Histamine intolerance, a condition characterized by the inability to properly metabolize histamine, can also cause similar symptoms.

Individuals with histamine intolerance may experience symptoms like hives, headaches, nasal congestion, gastrointestinal discomfort, and fatigue after consuming histamine-rich foods.

Benefits of Mastic Gum in Histamine Regulation

Given the potential of mastic gum to modulate histamine levels, it may offer some benefits to individuals who struggle with histamine intolerance or excessive histamine release. By helping maintain histamine levels within normal limits, mastic gum may help alleviate symptoms associated with histamine-related disorders.

However, it is essential to note that individual responses may vary, and it is always advisable to consult with a healthcare professional before making any dietary or supplement changes, especially if you have specific health concerns.

Other Natural Histamine Regulators

Foods that Lower Histamine Levels

In addition to mastic gum, there are several other natural substances that have been suggested to help regulate histamine levels in the body.

Foods like fresh vegetables, fruits, lean meats, and gluten-free grains are generally considered low in histamine and may be beneficial for individuals with histamine intolerance. On the other hand, fermented foods, aged cheeses, cured meats, and alcohol are known to be high in histamine and may exacerbate symptoms in sensitive individuals.

Herbs and Supplements for Histamine Control

Various herbs and supplements have also been proposed to support histamine control. These include quercetin, a natural antioxidant found in foods like onions and apples, and stinging nettle extract, which has anti-inflammatory properties and may help modulate histamine response.

However, it is important to discuss any supplement use with a healthcare professional to ensure safety and appropriateness, especially if you are currently taking any medications or have pre-existing medical conditions.


While mastic gum shows promise in modulating histamine levels and potentially offering benefits to individuals with histamine-related disorders, more research is needed to fully understand its mechanisms of action and optimal usage. It is always recommended to consult with a healthcare professional before making any dietary or supplement changes, particularly if you have specific health concerns or medical conditions. Histamine regulation should be approached comprehensively, considering various factors such as diet, lifestyle, and individual sensitivities.

Remember, everyone's body is unique, and what works for one person may not work for another. So, listen to your body, seek professional guidance, and make informed choices to support your overall health and well-being.

Back to blog

Keto Paleo Low FODMAP Cert, Gut & Ozempic Friendly

1 of 12

Keto. Paleo. No Digestive Triggers. Shop Now

No onion, no garlic – no pain. No gluten, no lactose – no bloat. Low FODMAP certified.

Stop worrying about what you can't eat and start enjoying what you can. No bloat, no pain, no problem.

Our gut friendly keto, paleo and low FODMAP certified products are gluten-free, lactose-free, soy free, no additives, preservatives or fillers and all natural for clean nutrition. Try them today and feel the difference!