A clinically-supported, multi-strain probiotic blend that uniquely addresses both digestive distress and stress-related symptoms through comprehensive gut-brain axis support. This specific combination is uniquely effective for addressing conditions involving the gut-brain axis, particularly:
- Irritable Bowel Syndrome (IBS)
- Antibiotic-Associated Digestive Disruption
- Stress-Related Digestive and Sleep Issues
- Immune System Dysregulation
Key Features
1. Synergistic Effects of the Seven-Strain Combination
This specific combination of probiotic strains creates powerful synergistic effects through:
- Comprehensive gut colonization: Different strains colonize different parts of the GI tract, providing complete coverage from the small intestine to the colon.
- Enhanced survival: The combination of spore-forming Bacillus subtilis with acid-resistant Lactobacillus strains and anaerobic Bifidobacterium strains ensures superior survival through the harsh gastric environment.
- Balanced immune modulation: Some strains stimulate immunity while others regulate excessive responses, creating a balanced immune effect.
- Comprehensive pathogen inhibition: Multiple antimicrobial mechanisms target a wider range of pathogens than single strains.
- Enhanced gut-brain axis support: Different strains influence the gut-brain axis through complementary pathways, providing more comprehensive neurological support.
2. Unique Health Conditions Addressed
Irritable Bowel Syndrome (IBS)
This blend is particularly effective for IBS due to its comprehensive approach:
Multiple strains (L. plantarum, L. acidophilus, B. longum) have demonstrated efficacy for IBS
Addresses various IBS symptoms through different mechanisms:
Reduces visceral hypersensitivity (L. rhamnosus, B. longum)
Improves gut motility (B. subtilis, L. casei)
Reduces gas production (L. acidophilus, L. plantarum)
Modulates gut-brain axis (B. breve, L. rhamnosus)
Reduces inflammation (B. longum, L. plantarum)
Strengthens gut barrier function (multiple strains)
Antibiotic-Associated Digestive Disruption
The blend provides exceptional protection during and after antibiotic use:
B. subtilis (DE111®): Spore-forming, highly resistant to antibiotics
L. rhamnosus and L. casei: Well-documented efficacy for antibiotic-associated diarrhea
B. longum and B. breve: Help restore beneficial bifidobacteria often depleted by antibiotics
L. acidophilus and L. plantarum: Support restoration of normal gut flora
Multiple mechanisms to prevent C. difficile colonization
Stress-Related Digestive and Sleep Issues
The combination uniquely addresses the gut-brain axis:
B. breve: Improves sleep quality and regulates HPA axis
L. rhamnosus: Reduces stress-induced corticosterone and anxiety-like behavior
B. longum: Influences brain activity and reduces stress
L. plantarum: Exhibits immunomodulatory effects that can reduce stress impact
L. acidophilus: Supports neurotransmitter production
Comprehensive support for both the digestive and neurological manifestations of stress
Immune System Dysregulation
The blend provides balanced immune modulation:
Multiple strains work through different pathways to balance immune response
Combination of immunostimulatory and immunoregulatory effects
Enhanced protection against both under-active and over-active immune responses
Particularly beneficial for recurrent infections and inflammatory conditions
Clinical Evidence Supporting Efficacy
Evidence for IBS
A randomized, placebo-controlled clinical trial by Ishaque et al. (2018) investigated a 14-strain probiotic formulation in 400 patients with moderate-to-severe IBS-D. The results showed:
69% reduction in abdominal pain severity for probiotic versus 47% for placebo (p < 0.001)
Reduction in patients rating symptoms as moderate-to-severe from 100% at baseline to 14% for probiotic at follow-up versus 48% for placebo (p < 0.001)
Significant reduction in number of bowel motions per day from month 2 onwards (p < 0.05)
Marked improvement in all dimensions of quality of life
Evidence for Antibiotic-Associated Diarrhea
A randomized, quadruple-blind, placebo-controlled trial by Łukasik et al. (2022) evaluated a multispecies probiotic consisting of Bifidobacterium and Lactobacillus strains in 350 children receiving antibiotics. The study found:
Reduction in overall risk of diarrhea regardless of etiology from 32% to 20% (RR, 0.65; 95% CI, 0.44-0.94)
No significant adverse events compared to placebo
The probiotic was well-tolerated during antibiotic treatment
Evidence for Stress-Related Digestive and Sleep Issues
A randomized, double-blind, placebo-controlled, cross-over clinical trial by Nobile and Puoci (2023) investigated a food supplement containing two probiotic strains, including Bifidobacterium breve, in supporting stress management in 33 healthy adults. The study found:
Significant reduction in Profile of Mood State (POMS) scores both versus baseline and placebo after 30 days
Significant improvement in Pittsburgh Sleep Quality Index (PSQI) scores both versus baseline and placebo after 30 days
Remarkable effect on stress management by improving quality of sleep and mood
Evidence for Immune System Regulation
A meta-analysis by Zhao et al. (2021) evaluated randomized trials of Lactobacillus plantarum on immune regulation. The analysis found:
Significant increase in anti-inflammatory IL-10 by 9.88 pg/mL (6.52 to 13.2; p < 0.05)
Significant decrease in pro-inflammatory TNF-α by 2.34 pg/mL (−3.5 to −1.19; p < 0.05)
Significant decrease in IFN-γ by 0.99 pg/mL (−1.56 to −0.41; p < 0.05)
Promotion of host immunity by regulating pro-inflammatory and anti-inflammatory cytokines
Individual Strain Contributions
DE111® (Bacillus subtilis)
Spore-forming capability provides exceptional shelf stability and gastric survival
Supports digestive health and regularity
Enhances immune function
Improves protein absorption
Reduces occasional gastrointestinal discomfort
Lactobacillus rhamnosus
Exceptional ability to adhere to intestinal mucosa
Prevents and treats diarrhea (including antibiotic-associated diarrhea)
Reduces symptoms of IBS
Influences mood and stress responses through the gut-brain axis
Modulates immune responses by balancing Th1/Th2 responses
Lactobacillus casei
Broad temperature and pH tolerance
Prevents and treats diarrhea
Enhances immune function
Improves lactose digestion
Positively affects mood and cognitive function
Bifidobacterium longum
Excellent colonization ability in the large intestine
Improves digestive comfort and regularity
Reduces inflammation in the gut
Influences brain function and behavior
Reduces anxiety and stress responses
Lactobacillus acidophilus
Excellent acid tolerance allowing survival in the stomach
Improves digestive health and comfort
Reduces symptoms of lactose intolerance
Prevents and treats diarrhea
Supports immune function
Lactobacillus plantarum
Exceptional adaptability to various environmental conditions
Regulates immune function
Improves symptoms of IBS
Enhances intestinal barrier function
Reduces inflammation
Bifidobacterium breve
Particularly effective at modulating the gut-brain axis
Improves cognitive functions
Enhances sleep quality
Supports immune function
Improves gastrointestinal health
This seven-strain probiotic blend containing DE111® (Bacillus subtilis), Lactobacillus rhamnosus, Lactobacillus casei, Bifidobacterium longum, Lactobacillus acidophilus, Lactobacillus plantarum, and Bifidobacterium breve offers unique and synergistic benefits for gut-brain axis health. This specific combination is "The Complete Gut-Brain Balance System" that addresses both digestive distress and stress-related symptoms through comprehensive gut-brain axis support.
Clinical evidence supports the efficacy and safety of multi-strain probiotics similar to this blend for IBS, antibiotic-associated digestive disruption, stress-related digestive and sleep issues, and immune system dysregulation. The synergistic effects of the seven strains provide comprehensive support for both digestive health and the gut-brain axis, resulting in superior outcomes compared to single-strain probiotics.
Comprehensive Probiotic Strains:
DE111® (Bacillus subtilis)
Lactobacillus rhamnosus
Lactobacillus casei
Bifidobacterium longum
Lactobacillus acidophilus
Lactobacillus plantarum
Bifidobacterium breve
References
Ishaque SM, et al. (2018). A randomized placebo-controlled clinical trial of a multi-strain probiotic formulation (Bio-Kult®) in the management of diarrhea-predominant irritable bowel syndrome. BMC Gastroenterology, 18:71.
Łukasik J, et al. (2022). Multispecies Probiotic for the Prevention of Antibiotic-Associated Diarrhea in Children: A Randomized Clinical Trial. JAMA Pediatrics, 176(9):948.
Nobile V, Puoci F. (2023). Effect of a Multi-Strain Probiotic Supplementation to Manage Stress during the COVID-19 Pandemic: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Clinical Trial. Neuropsychobiology.
Zhao W, et al. (2021). Meta-Analysis: Randomized Trials of Lactobacillus plantarum on Immune Regulation Over the Last Decades. Frontiers in Immunology.
Skrzydło-Radomańska B, et al. (2021). The Effectiveness and Safety of Multi-Strain Probiotic Preparation in Patients with Diarrhea-Predominant Irritable Bowel Syndrome: A Randomized Controlled Study. Nutrients, 13(3):756.
Lan Y, et al. (2023). Bifidobacterium breve CCFM1025 Improves Sleep Quality via Regulating the Activity of the HPA Axis: A Randomized Clinical Trial. Nutrients, 15(21):4700.
Marotta A, et al. (2023). Novel Multi-Strain E3 Probiotic Formulation Improved Mental Health. Nutrients, 15(24):5037.
Cuentas AM, et al. (2022). The Effect of Bacillus subtilis DE111 on the Daily Bowel Movement Profile for People with Occasional Gastrointestinal Irregularity. Journal of Probiotics & Health.
Ford AC, et al. (2023). Efficacy of Probiotics in Irritable Bowel Syndrome. Gastroenterology.
Szajewska H, et al. (2021). Probiotics for the Prevention of Antibiotic-associated Diarrhea in Adults. Journal of Clinical Gastroenterology.
Bagga D, et al. (2022). Multi-Strain Probiotic Mixture Affects Brain Morphology and Resting State. PMC.
Ianiro G, et al. (2024). High-dose Probiotic Mix of Lactobacillus spp., Bifidobacterium spp. for Prevention of Antibiotic-Associated Diarrhea. Open Forum Infectious Diseases.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.