Impact Assessment of Bacillus coagulans MTCC 5856 on Adults Suffering from Functional Gas and Bloating: A Thorough Analysis of a Randomized, Double-Blind, Placebo-Controlled Study

Digestive discomforts, such as functional gas and bloating, are common in adults. Recent studies have put forward the potential role of Bacillus coagulans MTCC 5856, a probiotic, in addressing these issues. This article presents a comprehensive evaluation of the "Effects of Bacillus coagulans MTCC 5856 on Functional Gas and Bloating in Adults" based on a randomized, double-blind, placebo-controlled study.


The research aimed to scrutinize the impact of a specific probiotic, Bacillus coagulans MTCC 5856 (otherwise known as LactoSpore®), on the manifestation of indigestion-associated symptoms. The target population consisted of adults experiencing mild-to-moderate indigestion.

Identification of the Problem

Indigestion, often resulting in functional gas and bloating, is a widespread issue among adults. This discomfort is primarily attributed to the imbalance in the gut microbiome, which is the collection of microorganisms residing in our digestive tract.

The Probiotic Solution

Bacillus coagulans MTCC 5856, a lactic-acid-producing probiotic, has shown promising results in restoring gut microbiome balance. This probiotic is recognized for its thermostable features, which allow it to survive harsh stomach conditions and reach the intestines effectively.

Research Design

The study was executed as a randomized controlled trial, involving 66 adults who had a higher-than-average Gastrointestinal Symptom Rating Scale (GSRS) indigestion score. Over four weeks, the participants were given either Bacillus coagulans MTCC 5856 tablets or a placebo.

Outcomes of Interest

The primary focus of the study was the GSRS indigestion subscale score and the global evaluation of patients' scores. Secondary outcomes included changes in other GSRS subscales and safety parameters.

Results and Findings

The research revealed a significant improvement in the indigestion subscale of GSRS and the global evaluation of patients' scores among the group receiving Bacillus coagulans MTCC 5856. The same group also experienced better results in all other GSRS subscales.

Reflection on the Results

The marked improvement observed in the group taking Bacillus coagulans MTCC 5856 denotes the potential of this probiotic in managing functional gas and bloating. However, it is essential to note that some of the study's authors were associated with the manufacturer of LactoSpore®, which might introduce an element of bias in the results.

Secondary Study: A Similar Approach

A parallel study, also following a randomized, double-blind, placebo-controlled design, was conducted among 70 adults with functional gas and bloating. This research validated the findings of the previous study, providing stronger evidence for the effectiveness of Bacillus coagulans MTCC 5856.

Critical Analysis of Both Studies

Both studies have underscored the potential of Bacillus coagulans MTCC 5856 in reducing gastrointestinal symptoms in adults. However, these results should be interpreted in the context of the potential bias in the first study and the limited sample size in both studies.


The effects of Bacillus coagulans MTCC 5856 on functional gas and bloating in adults, as examined in these randomized, double-blind, placebo-controlled studies, suggest a promising avenue for managing these common discomforts. Further research is needed to validate these findings and explore the long-term safety and efficacy of this probiotic.

"The marked improvement observed in the group taking Bacillus coagulans MTCC 5856 denotes the potential of this probiotic in managing functional gas and bloating." - Author Name


  1. Majeed M, Nagabhushanam K, Paulose S, Arumugam S, Mundkur L. The effects of Bacillus coagulans MTCC 5856 on functional gas and bloating in adults: A randomized, double-blind, placebo-controlled study. Medicine (Baltimore). 2023 Mar 3;102(9):e33109. doi: 10.1097/MD.0000000000033109. PMID: 36862903; PMCID: PMC9982755.


Note: This article is strictly for informational purposes and should not be used as a substitute for professional medical advice. Always consult your healthcare provider before starting any new treatment or supplement.

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