96 General Food Panel: IgG4 by US BioTek Vs YorkTest

In recent years, there has been growing interest in IgG4 food sensitivity testing as more and more people seek solutions for their health concerns. Two prominent players in the market offering IgG4 testing are US BioTek and YorkTest. In this article, we will delve into the intricacies of the 96 General Food Panel provided by these companies, evaluating their approaches and comparing their effectiveness.

Understanding IgG4 Food Sensitivity Testing

Before we examine the specifics, let's first gain a better understanding of IgG4 and its role in food sensitivity testing. IgG4 is a subclass of immunoglobulin G, a type of antibody found in our immune system. Unlike IgE, which is associated with immediate allergic reactions, IgG4 is primarily linked to delayed hypersensitivity reactions.

What is IgG4?

IgG4, as a subclass of immunoglobulin G, plays a crucial role in the immune response. It helps to neutralize harmful substances in our body, such as toxins and pathogens. Furthermore, IgG4 aids in maintaining immune homeostasis by preventing excessive inflammatory responses.

Immunoglobulin G (IgG) is the most abundant antibody in our bloodstream, accounting for approximately 75% of all antibodies. It is produced by plasma cells and is involved in both the innate and adaptive immune responses. IgG antibodies are versatile and can recognize a wide range of antigens, including bacteria, viruses, and other foreign substances.

IgG4, specifically, is known for its unique properties. It has a relatively low affinity for binding to antigens and has a slow dissociation rate. This means that IgG4 antibodies are less likely to trigger an immediate immune response compared to other antibody subclasses, like IgE.

The Role of IgG4 in Food Sensitivity

When it comes to food sensitivity, IgG4 antibodies are believed to react with specific food antigens in our body, triggering an immune response. This response can manifest as a wide range of symptoms, such as gastrointestinal issues, skin problems, and fatigue.

Food sensitivity is a complex condition that can be challenging to diagnose. IgG4 food sensitivity testing aims to identify IgG4 antibodies that are present in response to specific foods. By measuring the levels of IgG4 antibodies, healthcare professionals can gain insights into potential food sensitivities or intolerances.

It is important to note that IgG4 food sensitivity testing is still a subject of debate among medical professionals. Some argue that elevated IgG4 antibody levels do not necessarily indicate a true food sensitivity, as IgG4 antibodies can also be present in healthy individuals. However, proponents of IgG4 testing believe that it can provide valuable information and guide dietary interventions for individuals experiencing chronic symptoms related to food.

The process of IgG4 food sensitivity testing typically involves a blood sample collection. The collected sample is then analyzed in a laboratory, where the levels of IgG4 antibodies against specific food antigens are measured. The results are often presented in a report, indicating the levels of IgG4 antibodies for each tested food.

It's important to interpret the results of IgG4 food sensitivity testing with caution. Elevated IgG4 antibody levels alone do not confirm a food sensitivity, and further clinical evaluation may be necessary to establish a definitive diagnosis. Additionally, eliminating foods based solely on IgG4 test results can lead to unnecessary dietary restrictions and potential nutrient deficiencies.

Overall, IgG4 food sensitivity testing is a tool that can provide insights into potential food sensitivities. However, it should be used in conjunction with clinical evaluation and consideration of other factors, such as symptoms and medical history, to make informed decisions regarding dietary modifications.

An Overview of 96 General Food Panel

The 96 General Food Panel is a comprehensive test offered by both US BioTek and YorkTest. This panel aims to identify IgG4 reactions to a broad range of common food items, providing insight into potential food intolerances and sensitivities.

The test is designed to analyze the body's immune response to specific foods, specifically targeting IgG4 antibodies. IgG4 antibodies are associated with delayed immune reactions and can contribute to symptoms such as bloating, headaches, fatigue, and skin problems.

By testing for IgG4 reactions, the 96 General Food Panel can help individuals identify the specific foods that may be triggering their symptoms. This knowledge allows for targeted dietary modifications, which can lead to symptom relief and improved overall well-being.

The Purpose of a General Food Panel

The primary purpose of a general food panel is to identify potential food sensitivities that may be causing adverse reactions in individuals. It is important to note that food sensitivities are different from food allergies. While food allergies involve an immediate immune response, food sensitivities typically manifest as delayed reactions.

Food sensitivities can be challenging to identify without testing, as the symptoms can be subtle and vary from person to person. The 96 General Food Panel provides a comprehensive assessment of IgG4 reactions to a wide range of common food items, making it a valuable tool for individuals seeking to understand the potential triggers of their symptoms.

Identifying and eliminating trigger foods can lead to a reduction in symptoms such as digestive issues, skin problems, migraines, and chronic fatigue. Additionally, addressing food sensitivities can contribute to improved gut health and overall immune function.

What Does the 96 General Food Panel Test For?

The 96 General Food Panel tests for a wide variety of food items, including but not limited to dairy, gluten, eggs, nuts, and seafood. The panel covers a comprehensive range of commonly consumed foods, making it a valuable tool for individuals looking to gain insights into their potential food sensitivities.

In addition to the commonly tested foods, the panel also includes less common items such as spices, herbs, and specific fruits and vegetables. This broad testing scope ensures that individuals receive a comprehensive assessment of their potential trigger foods.

By examining IgG4 reactions to these foods, the test seeks to identify any potential triggers that may be contributing to an individual's symptoms. It is important to note that the presence of an IgG4 reaction does not necessarily indicate a food intolerance or sensitivity. The test results should be interpreted in conjunction with an individual's symptoms and medical history.

Once trigger foods are identified, healthcare professionals can work with individuals to develop personalized dietary plans that eliminate or reduce the consumption of these specific foods. This approach can lead to a reduction in symptoms and an improved quality of life for individuals struggling with food sensitivities.

US BioTek's Approach to IgG4 Testing

Now, let's delve into the specifics of how US BioTek carries out their IgG4 testing and what sets their approach apart.

When it comes to IgG4 testing, US BioTek follows a meticulous and scientifically rigorous process. They utilize a sophisticated technology called enzyme-linked immunosorbent assay (ELISA) to detect and quantify IgG4 antibodies. This method is widely accepted and validated in the field of immunology, known for its accuracy and reliability.

The ELISA-based approach employed by US BioTek involves several steps. First, a blood sample is collected from the individual undergoing testing. The sample is then processed in the laboratory, where it undergoes a series of carefully designed procedures to extract and isolate the IgG4 antibodies. These antibodies are then exposed to specific antigens that are representative of various food items.

During this process, if the individual has IgG4 antibodies specific to a particular food item, a reaction occurs between the antibodies and the corresponding antigens. This reaction is detected and quantified using specialized equipment that measures the intensity of the immune response.

The Science Behind US BioTek's IgG4 Test

US BioTek's utilization of ELISA technology brings a level of scientific rigor to their IgG4 testing. ELISA, being a well-established and widely used method, provides a solid foundation for accurate detection and quantification of IgG4 antibodies.

ELISA works by utilizing the principle of antigen-antibody interaction. In this case, the antigens used are specific to different food items, and the antibodies being detected are IgG4 antibodies. The specificity of this interaction ensures that only the relevant antibodies are detected, enhancing the precision of the test results.

Furthermore, US BioTek's ELISA-based approach allows for the simultaneous testing of multiple food items. Their extensive 96 General Food Panel covers a wide range of commonly consumed foods, providing comprehensive insights into an individual's IgG4 antibody reactivity. This broad coverage ensures that the test results offer a holistic view of potential food sensitivities.

Benefits and Limitations of US BioTek's Method

One of the key advantages of US BioTek's ELISA-based approach is its high level of precision, allowing for accurate detection of IgG4 antibodies. This precision enables individuals to identify specific food items that may be contributing to their symptoms or health concerns. Armed with this knowledge, individuals can make informed decisions regarding their diet and potentially alleviate discomfort or improve their overall well-being.

Additionally, the extensive 96 General Food Panel offered by US BioTek provides a comprehensive analysis of IgG4 antibody reactivity. This wide coverage ensures that individuals receive a thorough assessment of their potential food sensitivities, allowing for a more personalized approach to dietary modifications.

However, it's worth noting that US BioTek's testing method has some limitations. ELISA-based tests, including US BioTek's approach, are known to have a higher rate of false positives compared to other methods. This means that there is a possibility of detecting IgG4 antibodies that may not necessarily indicate a true food sensitivity.

To address this limitation, US BioTek emphasizes the importance of confirmatory tests. If a positive result is obtained through their IgG4 testing, it is recommended to follow up with additional testing methods or consultations with healthcare professionals. While this may add an extra step to the process, it ensures that the results are validated and provides individuals with a more accurate understanding of their food sensitivities.

Despite this limitation, US BioTek's ELISA-based approach remains a valuable tool in identifying potential food sensitivities and guiding individuals towards a more tailored and personalized approach to their diet.

YorkTest's Methodology for IgG4 Testing

In contrast to US BioTek's approach, let's now explore how YorkTest conducts their IgG4 testing and highlight the unique aspects of their methodology.

How YorkTest Conducts IgG4 Tests

YorkTest employs a proprietary technology known as enzyme-linked immunospot assay (ELIspot) to detect IgG4 antibodies. ELIspot is a highly sensitive method that provides an accurate assessment of IgG4 reactions to food antigens.

Pros and Cons of YorkTest's Approach

YorkTest's ELIspot-based method offers impressive sensitivity, making it a reliable tool for identifying IgG4 food sensitivities. Moreover, their comprehensive 96 General Food Panel covers a broad spectrum of commonly consumed foods.

However, the main drawback of YorkTest's approach is the higher cost compared to other testing options. Moreover, the turnaround time for results may be longer, which can be frustrating for individuals eagerly awaiting answers.

Comparative Analysis: US BioTek Vs YorkTest

Now that we have a good understanding of both companies' testing methodologies, let's compare and assess their performance based on two crucial factors: accuracy and cost.

Accuracy Comparison

Both US BioTek and YorkTest utilize reputable and scientifically validated methods for IgG4 testing. While the accuracy of each approach may vary slightly, both testing methods offer reliable results in the identification of IgG4 food sensitivities.

Cost Comparison

When it comes to cost, US BioTek generally offers a more budget-friendly option for individuals seeking IgG4 testing. On the other hand, YorkTest's proprietary technology and comprehensive panel drive up the overall cost of their testing services.

Turnaround Time Comparison

In terms of turnaround time, US BioTek typically provides faster results compared to YorkTest. This quick response can be especially valuable for individuals who are eager to make dietary changes promptly or seek further medical guidance based on the results.


The decision to opt for IgG4 food sensitivity testing is a personal one, and each individual's requirements may vary. Both US BioTek and YorkTest offer valuable insights into food sensitivities through their 96 General Food Panel. While US BioTek's ELISA-based testing method provides accurate results and a more cost-effective solution, YorkTest's ELIspot technology boasts high sensitivity, making it a reliable choice for individuals willing to invest in a more comprehensive approach. Ultimately, understanding the science behind IgG4 testing and considering personal needs will help individuals make informed decisions regarding their health and well-being.

Back to blog

Keto Paleo Low FODMAP Cert, Gut & Ozempic Friendly

1 of 12

Keto. Paleo. No Digestive Triggers. Shop Now

No onion, no garlic – no pain. No gluten, no lactose – no bloat. Low FODMAP certified.

Stop worrying about what you can't eat and start enjoying what you can. No bloat, no pain, no problem.

Our gut friendly keto, paleo and low FODMAP certified products are gluten-free, lactose-free, soy free, no additives, preservatives or fillers and all natural for clean nutrition. Try them today and feel the difference!